OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum

The Otx2 homeodomain transcription factor is essential for gastrulation and early neural development.We generated Otx2 conditional knockout (cKO) mice to investigate its metabo 15-gauge finish nailer cordless roles in telencephalon development after neurulation (approximately embryonic day 9.0).We conducted transcriptional profiling and in situ hyb

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Using Baidu search index to monitor and predict newly diagnosed cases of HIV/AIDS, syphilis and gonorrhea in China: estimates from a vector autoregressive (VAR) model

Objectives Internet search engine data have been widely used to monitor and predict infectious diseases.Existing studies have found correlations between search data and HIV/AIDS epidemics.We aimed to extend the literature through exploring the feasibility of using search data to monitor and predict the number of newly diagnosed 9002nc cases of HIV/

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Replicating animal mitochondrial DNA

The field of mitochondrial DNA (mtDNA) replication has been experiencing incredible progress in recent years, and yet little is certain about the mechanism(s) used by animal cells to replicate this plasmid-like genome.The long-standing strand-displacement model of mammalian mtDNA replication (for which single-stranded DNA intermediates are a hallma

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